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Active ingredient: Antihemophilic Factor - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Coagulants
  • Thrombotic Agents

Dosage Forms

  • Powder for solution
  • Solution (IV injection)

Brands / Synonyms

Advate; AHF; Alphanate; Bioclate; Coagulation factor VIII precursor; Helixate; Helixate FS; Hemofil M; Humate-P; Hyate:C; Koate-DVI; Koate-HP; Kogenate; Kogenate FS; Monarc-M; Monoclate-P; Nateglinide ; Procoagulant component; Recombinate; Refacto


Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells


For the treatment of hemophilia A, von Willebrand diseae and Factor XIII deficiency


Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.

Mechanism of Action

Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).


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Biotrnasformation / Drug Metabolism

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Drug Interactions

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