Brands, Medical Use, Clinical Data
- Thrombotic Agents
- Powder for solution
- Solution (IV injection)
Brands / Synonyms
Advate; AHF; Alphanate; Bioclate; Coagulation factor VIII precursor; Helixate; Helixate FS; Hemofil M; Humate-P; Hyate:C; Koate-DVI; Koate-HP; Kogenate; Kogenate FS; Monarc-M; Monoclate-P; Nateglinide
; Procoagulant component; Recombinate; Refacto
Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
For the treatment of hemophilia A, von Willebrand diseae and Factor XIII deficiency
Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.
Mechanism of Action
Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).
Biotrnasformation / Drug Metabolism