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Active ingredient: Antihemophilic Factor - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Coagulants
  • Thrombotic Agents

Dosage Forms

  • Powder for solution
  • Solution (IV injection)

Brands / Synonyms

Advate; AHF; Alphanate; Bioclate; Coagulation factor VIII precursor; Helixate; Helixate FS; Hemofil M; Humate-P; Hyate:C; Koate-DVI; Koate-HP; Kogenate; Kogenate FS; Monarc-M; Monoclate-P; Nateglinide ; Procoagulant component; Recombinate; Refacto

Description

Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells

Indications

For the treatment of hemophilia A, von Willebrand diseae and Factor XIII deficiency

Pharmacology

Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.

Mechanism of Action

Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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