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Active ingredient: Anakinra - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antirheumatic Agents
  • Immunomodulatory Agents

Dosage Forms

  • Solution

Brands / Synonyms

ICIL-1RA; IL-1ra; IL-1RN; IL1 inhibitor; Interleukin-1 receptor antagonist protein precursor; IRAP; Kineret; Kineret (Amgen Inc)

Description

Recombinant human interleukin-1 receptor antagonist. Has an extra Met at N-terminus, expressed in E. coli. 153 residues, MW=17.3 kD

Indications

For treatment of adult rheumatoid arthritis

Pharmacology

Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1.

Mechanism of Action

Kineret binds to the Interleukin-1 type I receptor (IL-1RI), thereby inhibiting the action of elevated levels IL-1 leading to cartilage degradation and bone resorption.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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