Chemisty and Biological Activity
Chemical Formula
C21H19N3O3S
Chemical Name
N-(4-acridin-9-ylamino-3-methoxy-phenyl)methanesulfonamide
Chemical Structure
Molecular Weight
393.46 g/mol
Physical State
Solid
Melting Point
234-236oC
Water Solubility
<1 mg/mL
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Glutathione S-transferase A1; Glutathione S-transferase A2
Primary Drug Target
| Name | DNA Topoisomerase II | | Gene Name | TOP2A | | Synonyms | DNA topoisomerase II, alpha isozyme; EC 5.99.1.3 | | General Function | Replication, recombination and repair | | Specific Function | Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks | | Reaction | ATP-dependent breakage, passage and rejoining of double-stranded DNA. |
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