Active ingredient: Amlexanox - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C16H14N2O4

Chemical Name

Not Available

Chemical Structure

Molecular Weight

298.293 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Cysteinyl leukotriene receptor 1
Gene Name	CYSLTR1
Synonyms	CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; HG55; HMTMF81
Specific Function	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4