Brands, Medical Use, Clinical Data
- Anti-Allergic Agents
- Antiulcer agent (topical)
- Anti-inflammatory, Locally Applied
Brands / Synonyms
Amlenanox; Amlexanox [USAN:INN:JAN]; Amlexanoxo [Spanish]; Amlexanoxum [Latin]; Amoxanox; Aphthasol; Elics; Solfa
Used as a paste in the mouth to treat aphthous ulcers (canker sores).
Amlexanox is a mucoadhesive oral paste which has been clinically proven to abort the onset, accelerate healing and resolve the pain of aphthous ulcers (canker sores). It decreases the time ulcers take to heal. Because amlexanox decreases the healing time, it also decreases the pain you feel. Recent studies have also shown that the majority of ulcers can be prevented by application of the paste during the prodromal (pre-ulcerative) phase of the disease. Recurrent Aphthous Ulcers (RAU) also known as Recurrent Aphthous Stomatitis (RAS) is recognized as the most common oral mucosal disease known to man. Estimates suggest that 20% - 25% of the general population suffer at least one incidence of aphthous ulcers each year.
Mechanism of Action
As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3.
No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract.
Biotrnasformation / Drug Metabolism
Metabolized to hydroxylated and conjugated metabolites.
Hypersensitivity to amlexanox or any component of the formulation.