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Active ingredient: Amitriptyline - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C20H23N

Chemical Name

3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1- propanamine

Chemical Structure

Molecular Weight

277.403 g/mol

Physical State

Solid

Melting Point

196-197 oC

Water Solubility

9.7 mg/mL

Isoelectric Point

9.4

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP1A2

Primary Drug Target
NameSodium-dependent serotonin re-uptake pump
Gene NameSLC6A4
SynonymsSodium-dependent serotonin transporter; 5HT transporter; 5HTT
General FunctionTransport activities and signal transduction
Specific FunctionTerminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals

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