DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Amitriptyline - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1- propanamine

Chemical Structure

Molecular Weight

277.403 g/mol

Physical State


Melting Point

196-197 oC

Water Solubility

9.7 mg/mL

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameSodium-dependent serotonin re-uptake pump
Gene NameSLC6A4
SynonymsSodium-dependent serotonin transporter; 5HT transporter; 5HTT
General FunctionTransport activities and signal transduction
Specific FunctionTerminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017