Chemisty and Biological Activity
Chemical Formula
C5H15N2O3PS
Chemical Name
2-(3-aminopropylamino)ethylsulfanylphosphonic acid
Chemical Structure
Molecular Weight
214.224 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
1000 mg/mL
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Alkaline phosphatase
Primary Drug Target
| Name | Alkaline phosphatase | | Gene Name | ENPP1 | | Synonyms | Ectonucleotide pyrophosphatase/phosphodiesterase 1; E-NPP 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1 [Includes: Alkaline phosphodiesterase I; EC 3.1.4.1; Nucleotide pyrophosphatase; EC 3.6.1.9; NPPase | | General Function | Catalytic activity and metabolism | | Specific Function | Has a broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. Can hydrolyze nucleoside 5' triphosphates such as ATP, GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate. Can hydrolyze diadenosine polyphosphates and 3',5'-cAMP to AMP. It may play a role in the regulation of pyrophosphate production, the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. | | Pathway | map00230 Purine metabolism
map00500 Starch and sucrose metabolism
map00740 Riboflavin metabolism
map00760 Nicotinate and nicotinamide metabolism
map00770 Pantothenate and CoA biosynthesis | | Reaction | A dinucleotide + H2O = 2 mononucleotides |
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