Brands, Medical Use, Clinical Data
- Anti-bacterial Agents
Brands / Synonyms
Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.
Amdinocillin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Amdinocillin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Amdinocillin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Amdinocillin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.
Mechanism of Action
Amdinocillin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2).
Poorly absorbed if given orally.
Biotrnasformation / Drug Metabolism