Basic Profile / Key Facts
Drug Category
Dosage Forms
Description
Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells
Indications
For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli
Pharmacology
Activase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. It also produces limited conversion of plasminogen in the absence of fibrin.
Mechanism of Action
Cleaves the Arg-Val bond in plasminogen to produce active plasmin.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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