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Active ingredient: Alteplase - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Thrombolytic Agents

Dosage Forms

  • Powder for solution

Brands / Synonyms

Activase; Activase (Genentech Inc) ; Cathflo Activase; Reteplase; t- PA; t-plasminogen activator; Tissue-type plasminogen activator precursor; tPA

Description

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells

Indications

For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli

Pharmacology

Activase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. It also produces limited conversion of plasminogen in the absence of fibrin.

Mechanism of Action

Cleaves the Arg-Val bond in plasminogen to produce active plasmin.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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