Chemisty and Biological Activity
Chemical Formula
C17H13ClN4
Chemical Name
8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Chemical Structure
Molecular Weight
308.765 g/mol
Physical State
Solid
Melting Point
228-228.5oC
Water Solubility
40 mg/L at pH 7; 12 mg/mL at pH 1.2
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
| Name | Gamma-aminobutyric-acid receptor alpha-1 subunit precursor | | Gene Name | GABRA1 | | Synonyms | GABA(A) receptor | | Specific Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates
neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening
an integral chloride channel |
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