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Active ingredient: Alendronate - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C4H13NO7P2

Chemical Name

(4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid

Chemical Structure

Molecular Weight

249.096 g/mol

Physical State

Solid

Melting Point

233 - 235 oC

Water Solubility

1mg/L

Isoelectric Point

2.72

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameFarnesyl pyrophosphate synthetase
Gene NameFDPS
SynonymsFPP synthetase; FPS; Farnesyl diphosphate synthetase[Includes: Dimethylallyltranstransferase, EC 2.5.1.1, Geranyltranstransferase, EC 2.5.1.10]
General FunctionCoenzyme transport and metabolism
Specific FunctionCatalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Pathwaymap00100 Biosynthesis of steroids map00900 Terpenoid biosynthesis
Reactiongeranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate

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