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Active ingredient: Alefacept - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C2306H3594N610O694S26

Chemical Name

Human LFA-3/IgG1 fusion protein

Chemical Structure

CFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSF KNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSP TLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKM ENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVIT TCIVLYMNGILKCDRKPDRTNSNRVEPKSCDKTHTCPPCPAPELLGGPSV FLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWYVDGVQVHNAKTK PREQQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENN YKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK

Molecular Weight

51801.1

Physical State

Liquid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

7.86

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameCD2 lymphocyte antigen
Gene NameCD2
SynonymsT-cell surface antigen CD2 precursor; T-cell surface antigen T11/Leu- 5; LFA-2; LFA-3 receptor; Erythrocyte receptor; Rosette receptor
Specific FunctionCD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggerring of T- cells, the cytoplasmic domain is implicated in the signaling function

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