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Active ingredient: Adinazolam - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antidepressants

Dosage Forms

  • Not Available

Brands / Synonyms

Adinazolam [Usan:Ban:Inn]; Adinazolam [Usan]; Adinazolamum [Inn-Latin]

Indications

For treatment of panic disorder

Pharmacology

Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex.

Mechanism of Action

Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Absorption

Not Available

Toxicity

Signs of overdose may include muscle weakness, ataxia, dysarthria and particularly in children paradoxical excitement. In more severe cases diminished reflexes, confusion, and coma may ensue.

Biotrnasformation / Drug Metabolism

Hepatic.

Contraindications

Hypersensitivity to adinazolam or other benzodiazepines. Adinazolam is also contraindicated in pregnancy, in infants and in patients with myasthenia gravis and acute narrow angle glaucoma.

Drug Interactions

Co-administration with antifungal agents such as ketoconazole or itraconazole is not recommended. Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction). Fluoxetine, OCs, sertraline, diltiazem, macrolide antibiotics (exercise caution).

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