Basic Profile / Key Facts
Drug Category
Dosage Forms
Indications
For treatment of panic disorder
Pharmacology
Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia. Adinazolam binds with high affinity to the GABA benzodiazepine receptor complex. Considerable evidence suggest that the central pharmacologic/therapeutic actions of alprazolam are mediated via interaction with this receptor complex.
Mechanism of Action
Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Absorption
Not Available
Toxicity
Signs of overdose may include muscle weakness, ataxia, dysarthria and particularly in children paradoxical excitement. In more severe cases diminished reflexes, confusion, and coma may ensue.
Biotrnasformation / Drug Metabolism
Hepatic.
Contraindications
Hypersensitivity to adinazolam or other benzodiazepines. Adinazolam is also
contraindicated in pregnancy, in infants and in patients with myasthenia gravis and acute narrow angle glaucoma.
Drug Interactions
Co-administration with antifungal agents such as ketoconazole or itraconazole is
not recommended. Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction). Fluoxetine, OCs, sertraline,
diltiazem, macrolide antibiotics (exercise caution).
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