Active ingredient: Adalimumab - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C6428H9912N1694O1987S46

Chemical Name

Humanized anti-TNF antibody (D2E7)

Molecular Weight

144190.3

Physical State

Liquid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

8.25

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Tumor necrosis factor alpha
Gene Name	TNF
Synonyms	Tumor necrosis factor precursor; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin
Specific Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation