Brands, Medical Use, Clinical Data
Drug Category
- Antirheumatic Agents
- Immunomodulatory Agents
Dosage Forms
Brands / Synonyms
Humira; Humira (Abbott Laboratories)
; Ig gamma-1 chain C region
Description
Anti-TNF antibody, expressed in mammalian cell culture, 1330 residues, MW=148 kD. Humira was created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgGl:K constant regions. It is produced by recombinant DNA technology in a mammalian cell expression system
Indications
For treatment of rheumatoid arthritis
Pharmacology
Used in the treatment of rheumatoid arthritis. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of the disease. Adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting the joint destruction.
Mechanism of Action
Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Most likely removed by opsonization via the reticuloendothelial system.
Contraindications
Not Available
Drug Interactions
Not Available
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