Chemisty and Biological Activity
Chemical Formula
C17H14N2O3
Chemical Name
1-ethyl-4-oxo-7-pyridin-4-yl-quinoline-3-carboxylic acid
Chemical Structure
D02305
Molecular Weight
294.305 g/mol
Physical State
Solid
Melting Point
290 oC
Water Solubility
Not Available
Isoelectric Point
Not Available
Organisms Affected
Enteric bacteria and other eubacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | DNA Topoisomerase II (bacterial) | | Gene Name | gyrB | | Synonyms | DNA gyrase subunit B; EC 5.99.1.3 | | General Function | Replication, recombination and repair | | Specific Function | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings | | Reaction | ATP-dependent breakage, passage and rejoining of double-stranded DNA |
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