Brands, Medical Use, Clinical Data
Brands / Synonyms
Eracine; Eradacil; Eradacin; ROS; Rosoxacin; Rosoxacin [Usan:Inn]; Rosoxacine [Inn-French]; Rosoxacino [Inn-Spanish]; Rosoxacinum [Inn-Latin]; Roxadyl; Winuron
For the treatment of Bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients
Acrosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Acrosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Mechanism of Action
Acrosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Biotrnasformation / Drug Metabolism