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Active ingredient: Acitretin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C21H26O3

Chemical Name

9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8- tetraenoic acid

Chemical Structure

Molecular Weight

326.429 g/mol

Physical State

Solid

Melting Point

228-230 oC

Water Solubility

0.0729 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameRetinoic acid receptor alpha
Gene NameRARA
SynonymsRetinoic acid receptor alpha; RAR-alpha
Specific FunctionThis is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression

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