Active ingredient: Acebutolol - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C18H28N2O4

Chemical Name

N-[3-acetyl-4-(2-hydroxy-3-propan-2-ylamino-propoxy)-phenyl]butanamide

Chemical Structure

Molecular Weight

336.426 g/mol

Physical State

Solid

Melting Point

119-123 oC

Water Solubility

259 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2D6

Primary Drug Target

Name	Beta-1 Adrenergic Receptor
Gene Name	ADRB1
Synonyms	Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor
General Function	Receptor activity and cell communication
Specific Function	Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximatively equal affinity