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[Evaluation of the effectiveness of prostacyclin in the treatment of thrombosis of the central retinal vein using a double-blind method]. [Article in Polish]

Author(s): Zygulska-Mach H(1), Mirkiewicz-Sieradzka B, Kostka-Trabka E, Grodzińska LL, Dembińska-Kieć AD, Romanowska B, Bieroń K, Kedzior A, Basista MM.

Affiliation(s): Author information: (1)Kliniki Okulistycznej AM w Krakowie.

Publication date & source: 1992, Klin Oczna. , 94(1):13-5

The patients were divided by chance into 2 groups: the first one (15 persons) was given a natrium salt of prostacyclin (Epoprostenol Wellcome or Chinoin) in a dose of 5 mg/kg/min. intravenously by an infusion pump in 5 infusions; the control group (15 persons) received instead of prostacyclin a placebo (0.1 M glycine buffer of pH 10.5). Besides all the patients were given Doxium or Calcium dobesilate, Rutinoscorbin, Vitamin C, and Polopyrin S (Soluble Aspirin). Immediately after the completion of the treatment the authors did not find any essential differences between the examined groups. In prolonged observations however one demonstrated a significantly smaller frequency of the development of neovascularization in the eyes of persons treated by prostacyclin in comparison with the control group.

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