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The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum.

Author(s): Ziaei S, Hosseiney FS, Faghihzadeh S

Affiliation(s): Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran.

Publication date & source: 2004-03, Acta Obstet Gynecol Scand., 83(3):272-5.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND: To determine whether low dosages of prednisolone are effective in the treatment of outpatients with hyperemesis gravidarum. METHODS: Eighty pregnant women with gestational ages of 6 to 12 weeks and persistent nausea and vomiting participated. The women were assigned by simple randomization to receive prednisolone 5 mg daily or promethazine 75 mg daily by oral route for 10 days. The severity of nausea, frequency of vomiting per day, sickness and the drugs' side-effects were compared (Fisher's exact test, Mann-Whitney U-test, Odds Ratio test). RESULTS: The women who received promethazine responded better in the first 48 h (p = 0.02). With continuation of the treatment, the difference decreased, and one week after completion of the treatment, the subjects who had received prednisolone had less symptoms. CONCLUSION: Promethazine reduces the symptoms of hyperemesis gravidarum faster than prednisolone, but during prolonged treatment, prednisolone has at least the same effects on the symptoms and less drug side-effects.

Page last updated: 2006-01-31

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