Adapalene gel 0.1%: effective and well tolerated in the topical treatment of acne vulgaris in Chinese patients.

Author(s): Zhu XJ, Tu P, Zhen J, Duan YQ

Affiliation(s): Department of Dermatology, Peking University First Hospital, Beijing, People's Republic of China.

Publication date & source: 2001-10, Cutis., 68(4 Suppl):55-9.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

Acne vulgaris is a common dermatologic disease in Asian populations, as well as in Caucasians. Our objective was to evaluate the safety and efficacy of adapalene gel 0.1% in comparison with tretinoin gel 0.025% in Chinese patients with acne vulgaris. We used an 8-week, multicenter, randomized, controlled, investigator-masked, parallel group design study of adapalene gel 0.1% and tretinoin gel 0.025% in 150 Chinese patients with mild-to-moderate acne vulgaris. Our results showed that adapalene gel 0.1% had efficacy equivalent to tretinoin gel 0.025% against acne lesions in Chinese patients, with a more acceptable tolerability profile.