Application of lornoxicam to patient-controlled analgesia in patients undergoing abdominal surgeries.

Author(s): Zhao H, Ye TH, Gong ZY, Xue Y, Xue ZG, Huang WQ

Affiliation(s): Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730.

Publication date & source: 2005-03, Chin Med Sci J., 20(1):59-62.

Publication type: Comparative Study ; Multicenter Study; Randomized Controlled Trial

OBJECTIVE: To assess the efficacy and safety of lornoxicam, one non-steroidal anti-inflammatory drug (NSAID) in patient-controlled analgesia (PCA) in patients undergoing abdominal surgeries. METHODS: Thirty-nine patients scheduled for abdominal surgeries were randomly assigned to different PCA treatment groups using either lornoxicam or fentanyl postoperatively. Pain intensity difference (PID) and sum of pain intensity difference (SPID) were used to assess the analgesic efficacy of both drugs during a 24-hour period. RESULTS: The analgesic efficacy of lornoxicam is 1/66 of fentanyl, which was shown by SPID value of 3.250 and 3.058, respectively (P > 0.05). Lornoxicam caused fewer adverse events than fentanyl (33% vs. 68%, P < 0.05). CONCLUSION: In clinic, we can use lornoxicam to treat postoperative pain effectively and with less adverse reactions compared with fentanyl.