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Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial.

Author(s): Zhang Q, Simoneau G, Verstuyft C, Drouet L, Bal dit Sollier C, Alvarez JC, Rizzo-Padoin N, Bergmann JF, Becquemont L, Mouly S

Affiliation(s): University of Paris VII-Denis Diderot, Therapeutic Research Unit, Department of Internal Medicine, Lariboisiere Hospital, Paris, France.

Publication date & source: 2011-02, Br J Clin Pharmacol., 71(2):232-6.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

AIMS: To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy. METHODS: In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo. RESULTS: The mean maximum increase in INR observed was 0.22 +/- 0.3 with amoxiclav vs. 0.24 +/- 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S(-) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P=0.81, P=0.45, P=0.75, respectively). CONCLUSION: Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection. (c) 2011 The Authors. British Journal of Clinical Pharmacology (c) 2011 The British Pharmacological Society.

Page last updated: 2011-12-09

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