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Topiramate as an adjunctive treatment for refractory partial epilepsy in the elderly.

Author(s): Zhang L, Huang J, Zhuang JH, Huang LQ, Zhao ZX

Affiliation(s): Department of Neurology, Changzheng Hospital, The Second Military Medical University, Shanghai, China.

Publication date & source: 2011, J Int Med Res., 39(2):408-15.

Publication type: Randomized Controlled Trial

This double-blind, placebo-controlled study investigated the efficacy and tolerability of adjunctive topiramate in 86 elderly Chinese patients with refractory partial epilepsy. Patients who had at least four seizures per 4 weeks during an 8-week baseline period, despite medication with up to three standard antiepileptic drugs (AEDs), were randomly assigned to receive topiramate (n = 46) or placebo (n = 40). Topiramate dosages were titrated (target dose 200 mg/day orally) for 8 weeks and maintained at stable levels for another 12 weeks; concomitant AEDs continued at original dosages. All patients completed the study: 47.8% in the topiramate group and 7.5% on placebo reached >/= 50% reduction in complex partial seizures. In the topiramate group, the most common adverse events were dizziness, somnolence, fatigue, headache and difficulty with memory; most events were transient and mild or moderate in severity. It was concluded that 200 mg/day topiramate was effective and well-tolerated in elderly patients with refractory partial epilepsy.

Page last updated: 2011-12-09

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