[Treatment of allergic rhinitis with asthma by different ways of inhaling corticosteroids]

Author(s): Zhang H, Chen X, Wang HW, Xiang YB

Affiliation(s): Department of Otorhinolaryngology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, China. hzhang1106@yahoo.com.cn

Publication date & source: 2009-01, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi., 44(1):16-20.

Publication type: English Abstract

OBJECTIVE: To observe the therapeutical effect on allergic rhinitis with asthma by different ways of inhaling corticosteroids. METHODS: Ninety patients suffering from allergic rhinitis with asthma were classified into three groups in random and treated with budesonide (BUD) by nasal spray, inhaling and nasal spray-inhaling combined administration for 12 weeks, respectively. The concentration of serum total IgE, eosinophil cationic protein (ECP) and IL-5, pulmonary functions were examined before and after treatment. RESULTS: The improvement of symptom scores of rhinitis and asthma in three groups were significant (P < 0.05). The concentration of serum total IgE, ECP and IL-5 in three groups decreased greatly after treatment (P < 0.05). There were significant improvement in FEV1, FEV1/FVC and FEF25%-75% in inhaling group before and after treatment (P < 0.05): FEV1 from (2.04 +/- 0.45) L to (2.47 +/- 0.54) L, FEV1/FVC from (72.73 +/- 5.59)% to (75.42 +/- 5.94)% and FEF25%-75% from 1.69 +/- 0.52 to 2.06 +/- 0.77. There was also significant improvement in nasal spray-inhaling combined groups before and after treatment (P < 0.05): FEV1 from (2.32 +/- 0.56) L to (2.76 +/- 0.58) L, FEV1/FVC from (73.80 +/- 4.17)% to (76.04 +/- 4.49)% and FEF25%-75% from 2.09 +/- 0.45 to 2.34 +/- 0.64. The significant difference of FEV1 among the three treatment groups was observed (P = 0.041). CONCLUSIONS: The symptoms of rhinitis and asthma in three groups by three ways of inhaling BUD were greatly improved, no significant difference in symptom scores and serum parameters was found.