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[Investigations of poisonings with benzodiazepine derivatives mixtures by thin-layer chromatography]

Author(s): Zevzikoviene A, Zevzikovas A, Bertulis A

Affiliation(s): Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, A. Mickeviciaus 9, 3000 Kaunas, Lithuania. augusta@kaunas.init.lt

Publication date & source: 2003, Medicina (Kaunas)., 39(11):1100-2.

The thin-layer chromatography method was proposed for separation and identification of drugs in mixture alprazolam : brotizolam : clorazepate dipotassium. The mixture of these drugs excreted from body fluid (blood) was investigated by the thin-layer chromatography. Most acceptable is this mobile phase : benzene : dioxane : conc. ammonia : methanol : ethanol (60:25:5:10:10). Rf values for drugs: alprazolam 0.81-0.83, brotizolam 0.59-0.62, clorazepate dipotassium 0.67-0.69.

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