Two year follow-up of clinical and inflammation parameters in children
monosensitized to mites undergoing subcutaneous and sublingual immunotherapy.
Author(s): Yukselen A(1), Kendirli SG, Yilmaz M, Altintas DU, Karakoc GB.
Affiliation(s): Author information:
(1)Clinic of Pediatric Allergy and Immunology, Children's Hospital of Gaziantep,
Gaziantep, Turkey.
Publication date & source: 2013, Asian Pac J Allergy Immunol. , 31(3):233-41
BACKGROUND: Both SCIT (subcutaneous immunotherapy) and SLIT (sublingual
immunotherapy) have clinical and immunologic efficacy in children with rhinitis
and asthma but comparative studies are scarce.
OBJECTIVE: To investigate the clinical and immunological efficacy of
mite-specific SLIT and SCIT in children with rhinitis and asthma.
METHOD: Thirty children monosensitized to house dust mite were randomized to
receive either active SCIT or SLIT or placebo for 1 yr in a double-blind
double-dummy placebo controlled design (Yukselen A et al., Int Arch Allergy
Immunol 2012; 157:288-298). Thereafter, the placebo group was randomized to
receive SCIT or SLIT, and for 1 yr all patients received active treatment with
SCIT or SLIT. Symptom scores, drug usage, titrated skin prick tests, nasal and
bronchial allergen provocation doses, serum house dust mite-specific
immunglobulin E, sIgG4, IL-10 and IFN- g levels were evaluated.
RESULTS: The reduction of clinical scores with SLIT was more evident after 2
years of treatment in comparison to both the baseline and DBPC phase of the
study. The change in titrated skin prick tests and nasal provocative doses was
more prominent with both SCIT and SLIT at the end of the open phase. Although the
increase inbronchial provocative doses was not significant at the end of the
first year of treatment with SLIT, it reached a statistically significant
difference after two years of treatment.
CONCLUSION: The clinical efficacy of SLIT is more prominent at the end of the
second year, although this improvement is observed from the first year of
treatment with SCIT in mite-sensitive children.
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