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[The ocular hypotensive effect and safety of 0.2% brimonidine]

Author(s): Yu M, Li Y, Ge J

Affiliation(s): Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.

Publication date & source: 2001-12, Yan Ke Xue Bao., 17(4):235-8.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To study the ocular hypotensive efficacy and safety of 0.2% Brimonidine when used in chinese people. METHODS: Using randominzed parallel group control study, 0.2% Brimonidine twice a day or 1% Carteolol twice a day was applied in patients with primary open angle glaucoma or ocular hypertension for three months. RESULTS: The results showed that 0.2% Brimonidine and 1% Carteolol both have good ocular hypotensive efficacy. There was no significant difference between them. 0.2% Brimonidine did not produce significant changes in pupil size and heart rate. Change in blood pressure was not clinically significant. Six patients with 0.2% Brimonidine had drowsiness. Two patients had dry mouth. One patient had ocular burning. CONCLUSION: Our results suggested that 0.2% Brimonidine would be a stable and effective antiglaucoma medicine with good tolerance. Thus, 0.2% Brimonidine should be the main choice of medical therapy for primary open angle glaucoma and ocular hepertension.

Page last updated: 2006-01-31

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