Postoperative oral amiodarone as prophylaxis against atrial fibrillation after coronary artery surgery.

Author(s): Yazigi A, Rahbani P, Zeid HA, Madi-Jebara S, Haddad F, Hayek G

Affiliation(s): Department of Anesthesia and Intensive Care, Hotel-Dieu de France Hospital, Saint-Joseph University, Beirut, Lebanon.

Publication date & source: 2002-10, J Cardiothorac Vasc Anesth., 16(5):603-6.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To assess the prophylactic effect of postoperative oral amiodarone on the incidence and severity of atrial fibrillation (AF) after coronary artery surgery. DESIGN: Prospective, randomized, blinded, controlled study. SETTING: University hospital. PARTICIPANTS: Patients who had coronary artery surgery (n = 200). INTERVENTIONS: Patients in group 1 (n = 100) received oral amiodarone, 15 mg/kg, 4 hours after arrival in the intensive care unit, followed by 7 mg/kg/d until hospital discharge. Patients in group 2 (n = 100) received placebo. MEASUREMENTS AND MAIN RESULTS: Incidence, duration, and recurrence of new episodes of AF and maximal ventricular rate response were recorded from day 0 until hospital discharge. Side effects related to amiodarone and complications induced by new-onset AF were noted. The incidence of new-onset AF (12% v 25%) and maximal ventricular rate response (120 +/- 21 beats/min v 135 +/- 24 beats/min) were significantly lower in the amiodarone group. There were no side effects related to the administration of amiodarone. The incidence of complications induced by AF was comparable between the 2 groups. CONCLUSION: Postoperative prophylactic oral amiodarone after coronary artery surgery is safe and effective in reducing the incidence of new-onset AF and maximal ventricular rate response. Copyright 2002, Elsevier Science (USA). All rights reserved.