Zonisamide-induced weight loss in schizophrenia: case series.

Author(s): Yang J, Lee MS, Joe SH, Jung IK, Kim SH

Affiliation(s): Department of Psychiatry, Korea University College of Medicine, Korea University Research Institute of Mental Health, Seoul, South Korea.

Publication date & source: 2010-03, Clin Neuropharmacol., 33(2):104-6.

Publication type: Case Reports

Weight gain and metabolic disturbances constitute bothersome problems in schizophrenic patients treated with atypical antipsychotics. Several medications, exercise regimens, and lifestyle changes have been used in attempts to ameliorate these problems. We describe 3 patients with schizophrenia who manifested distinct weight loss and reduction in waist circumference during medication with zonisamide. This report suggests that zonisamide might be associated with weight loss in patients with schizophrenia.