[Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention]
Author(s): Yang C, Li YL, Fang J, Zhang X, Liu HP, Qin XH, Xu XP
Affiliation(s): Anhui Provincial Institute of Biomedicine, Anhui Medical University, Hefei, Anhui 230032, China.
Publication date & source: 2009-05, Zhonghua Nan Ke Xue., 15(5):441-4.
Publication type: English Abstract; Randomized Controlled Trial
OBJECTIVE: This prospective randomized double-blinded clinical trial was designed to explore the effects of amlodipine and the combination of amlodipine with terazosin in improving postvoid residual (PVR) in patients with lower urinary tract symptoms (LUTS) and concomitant hypertension. METHODS: We randomly divided 360 LUTS patients with concomitant hypertension into a 5 mg amlodipine group, a 2 mg terazosin group and a 5 mg amlodipine plus 2 mg terazosin group, and measured PVR at the baseline and 4 weeks after the treatment. RESULTS: For male patients with LUTS associate with hypertension, all of amlodipine (APVR = 6.8) , terazosin (APVR = 7. 6), and combination group (APVR = 8.8) can significant reduced the PVR (P < . 0.1), but no significant difference was found among three groups. CONCLUSION: Amlodipine alone or combined with terazosin can improve the PVR of the LUTS patient effectively, but had no significant difference compared with terazosin.