[Effects of preoperatively administered flurbiprofen axetil on the action of inhaled anesthesia and postoperative pain]

Author(s): Yamazaki Y, Sonoda H, Seki S

Affiliation(s): Department of Anesthesia, Kushiro City General Hospital.

Publication date & source: 1995-09, Masui., 44(9):1238-41.

Publication type: Clinical Trial; English Abstract; Randomized Controlled Trial

Flurbiprofen axetil (FP) was evaluated in a randomized study relative to placebo in 26 patients undergoing endonasal ethmoidectomy. The FP group (n = 13) was administrated 1 mg.kg-1 FP 15 minutes before operation during a half hour. Likewise, the control group (n = 13) received intravenous NaCl 0.9%. Concentration and the quantity consumed of sevoflurane, perioperative body temperature, postoperative pain and on-demand dicrofenac sodium consumption were measured. No significant differences were observed concerning concentration and the quantity consumed of sevoflurane. Body temperature of the FP group fell significantly before infusion. The FP group showed lower pain scores and required less dicrofenac sodium than the control group (P < 0.05). This study suggests that preoperative FP infusion relieves postoperative pain, but does not affect the action of the inhalation anesthetic.