[Effect of antibiotics on postoperative inflammatory complications after surgical
extraction of the impacted mandibular third molar]. [Article in Chinese]
Author(s): Xue P(1), Hou R(2), Shang L, Ma Y, Wu F, Zhang S.
Affiliation(s): Author information:
(1)State Key Laboratory of Military Stomatology, Department of Oral and
Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical
University, Xi'an 710032, China. (2)Email: hourui@fmmu.edu.cn.
Publication date & source: 2014, Zhonghua Kou Qiang Yi Xue Za Zhi. , 49(10):603-6
OBJECTIVE: To investigate the effect of antibiotics on postoperative inflammatory
complications after surgical extraction of the impacted mandibular third molar.
METHODS: Ninety-Six patients had their bilateral third molars removed through a
split-mouth, double-blind, controlled, clinical trial in two visits. On one side
amoxicillin (or clindamycin) was used (antibiotics group) from 1 h pre-operation
to 3 d post-operation. On the other side, placebo was used (placebo group) the
same time. Postoperative inflammatory complications including alveolar osteitis
(AO), surgical site infection (SSI), pre-buccal site infection and anterior
isthmus faucium space infection were monitored and recorded 2 d and 10 d after
the surgery. The pain, swelling, and trismus were also recorded.
RESULTS: All 96 patients completed the study. Two AO (2.1%), one SSI (1.0%) and
seven other infections were observed in the treatment group. Also three AO
(3.1%), one SSI (1.0%) and eleven other infections were observed in the placebo
group. However, no statistically significant differences were found in the
incidence of various postoperative inflammatory complications and reactions
between the groups (P > 0.05). There was no significant difference on the
postoperative reaction, except pain on 10 d. Patients who had inflammatory
infection recovered well with symptomatic anti-infection treatment.
CONCLUSIONS: The use of amoxicillin (or clindamycin) cannot effectively prevent
and reduce the postoperative inflammatory complications after surgical extraction
of the impacted mandibular third molar.
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