[Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children]

Author(s): Xiang L, Wen FQ, Zuo WH, Tang Y

Affiliation(s): Department of Pediatrics, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen, Guangdong 518020, China.

Publication date & source: 2007-06, Zhongguo Dang Dai Er Ke Za Zhi., 9(3):205-6.

Publication type: English Abstract; Research Support, Non-U.S. Gov't

OBJECTIVE: To study the efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for Helicobactor pylori (H. pylori) infection in children. METHODS: One hundred and five children with H. pylori infection identified by 13C-UBT were randomly assigned into Group A (n=60) and Group B (n=45). The patients of the two groups were administered with 1 week or 2 weeks triple therapy consisting of esomeprazole, clarithromycin and amoxillin, respectively. They were followed up four weeks after drug withdrawal. RESULTS: Recurrent abdominal pain was relieved in all of patients. Fifty-five patients (91.7%) showed 13C-UBT negative in Group A and 42 (93.3%) presented negative in Group B. There was no significant difference in the eradication rate of H. pylori. CONCLUSIONS: Esomeprazole-based triple therapy for H. pylori infection is effective in children. The efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for this disorder does not appear to be different.