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[Therapeutic effects of traditional Chinese herbal formula with Smilax glabra on mice's lead poisoning]

Author(s): Xia DZ, Wang HM, Yang Q, Jiang LQ, Xia M

Affiliation(s): College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. xiadaozong@zjtcm.net

Publication date & source: 2009-03, Zhong Yao Cai., 32(3):404-6.

Publication type: English Abstract; Research Support, Non-U.S. Gov't

OBJECTIVE: To investigate the influence of traditional Chinese herbal formula with Smilax glabra on lead expelling and oxidative damage in lead-poisoned mice. METHODS: Mice were received intraperitoneal injections of lead acetate to establish lead-poisoned models. The concentration of lead, zinc and copper in blood, brain, liver, kidney and bone were determined. The lipid peroxidation of liver was systematically evaluated. RESULTS: The traditional Chinese herbal formula had no influence on body weight and organ weight/body weight ratio of lead-poisoned mice. The traditional Chinese herbal formula might significantly reduce the concentration of lead in blood, rain, liver, kidney and bone, and the rate were 74%, 48%, 56%, 51% and 44%, but had no influence on zinc's and copper' s concentration. The decreasing rate of MDA levels in liver by the traditional Chinese herbal formula was 31%. In addition, the increase rate of GSH levels and the activities of GSH-Px and SOD in liver by traditional Chinese herbal formula were 63% ,76% and 66%, respectively. CONCLUSIONS: The traditional Chinese herbal formula with Smilax glabra can significantly advance the excretion of lead and protect liver against oxidative damage induced by lead.

Page last updated: 2009-10-20

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