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Comparison of clotrimazole, fluconazole and itraconazole in vaginal candidiasis.

Author(s): Woolley PD, Higgins SP

Affiliation(s): Department of Genitourinary Medicine, University Hospital of South Manchester.

Publication date & source: 1995-03, Br J Clin Pract., 49(2):65-6.

Publication type: Clinical Trial; Randomized Controlled Trial

Women attending a genitourinary medicine clinic (n = 229) with mycologically confirmed acute vulvovaginal candidiasis were randomised to receive either clotrimazole (500 mg pessary and 1% cream), fluconazole (150 mg single oral dose) or itraconazole (200 mg bd oral dose for 1 day). Mycological cure rates were 96% in the itraconazole group, 95% in the clotrimazole group, and 83% in the fluconazole group (P = 0.008). The proportion of patients who were clinically cured showed a similar pattern (itraconazole 80%, clotrimazole 80%, fluconazole 62%). This suggests that itraconazole or clotrimazole are more effective than fluconazole in the treatment of acute vaginal candidiasis.

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