Nepafenac-associated corneal melt.

Author(s): Wolf EJ, Kleiman LZ, Schrier A

Affiliation(s): Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. ericwolfmd@yahoo.com

Publication date & source: 2007-11, J Cataract Refract Surg., 33(11):1974-5.

Publication type: Case Reports

We describe a patient with systemic graft-versus-host disease who developed a nonhealing epithelial defect after cataract surgery that healed on cessation of a topical nonsteroidal antiinflammatory drug (NSAID) (ketorolac). The patient developed a central corneal perforation in the fellow eye while on a new NSAID formulation (nepafenac) after routine cataract surgery. Our case suggests that new topical NSAIDs may be similar to older NSAID formulations in promoting corneal melting in patients predisposed to poor epithelialization and corneal wound healing.