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Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis. I. Efficacy results.

Author(s): Wheeler JM, Knittle JD, Miller JD

Affiliation(s): Center for Reproductive Medicine and Surgery, Baylor College of Medicine, Houston, Texas.

Publication date & source: 1992-11, Am J Obstet Gynecol., 167(5):1367-71.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

OBJECTIVE: We aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis. STUDY DESIGN: A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods. RESULTS: When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis. CONCLUSION: Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.

Page last updated: 2006-01-31

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