Effects of the angiotensin converting enzyme inhibitor, benazepril, on the sino-aortic baroreceptor heart rate reflex.
Author(s): West JN, Champion de Crespigny PC, Stallard TJ, Littler WA
Affiliation(s): Department of Cardiovascular Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.
Publication date & source: 1991-08, Cardiovasc Drugs Ther., 5(4):747-51.
Publication type: Clinical Trial; Randomized Controlled Trial
The effects of monotherapy with the angiotensin converting enzyme inhibitor benazepril (10 mg once daily) on cardiovascular baroreceptor reflexes were determined in 10 patients with essential hypertension using a randomized, double-blind, placebo-controlled, cross-over protocol. Early sino-aortic baroreceptor/heart rate reflex resetting was apparent with acute treatment; this effect persisted throughout the active treatment period. Changes in baroreflex sensitivity did not appear to mediate the hypotensive effect of benazepril.
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