[Efficacy of paliperidone extended-release tablets in the improvement of social
functions in schizophrenics: a randomized and controlled study]. [Article in Chinese]
Author(s): Wang Y, Li WS, Gu DK, Yang N, Lu Y, Zhang Y, Cao Y, Bai LD.
Affiliation(s): Department of Psychiatry, School of Medicine, Shandong University, Jinan 250012,
China. wangyang@sdu.edu.cn
Publication date & source: 2010, Zhonghua Yi Xue Za Zhi. , 90(29):2030-5
OBJECTIVE: To explore the efficacy of paliperidone extended-release tablets in
the improvement of social functions in schizophrenics.
METHODS: A total of 81 schizophrenics were randomly divided into study group with
paliperidone extended-release tablets and control group with risperidone for a
12-week treatment. They were assessed and analyzed by positive and negative
symptoms scales (PANSS), social disability screening schedule (SDSS) and
treatment emergent symptom scale (TESS) at baseline, 6(th) weekend and 12(th)
weekend.
RESULTS: In study group, the factors and total scores of PANSS in the 12(th)
weekend of treatment [(12.0 ± 2.8), (12.1 ± 3.6), (26.2 ± 5.0), (50.2 ± 8.7)]
were all significantly lower than those at baseline [(24.7 ± 5.3), (23.8 ± 3.6),
(45.0 ± 2.9), (93.5 ± 6.8)] (t = 9.60-16.78, P < 0.05). In study group, the
positive factor, negative factor and total scores of PANSS in the 12(th) weekend
of treatment [(12.0 ± 2.8), (12.1 ± 3.6), (50.2 ± 8.7)] were all significantly
lower than those in the 6(th) weekend of treatment [(14.2 ± 1.8), (14.6 ± 2.4),
(56.5 ± 6.4)] (t = 2.58-4.26, P < 0.05). In the 12(th) weekend of treatment, the
factors and total scores of PANSS in study group [(12.0 ± 2.8), (12.1 ± 3.6),
(26.2 ± 5.0), (50.2 ± 8.7)] were all significantly lower than those in control
group [(16.9 ± 4.9), (18.7 ± 5.3), (32.5 ± 5.1), (68.1 ± 13.0)] (t = -4.28--5.67,
P < 0.05). In study group, the total scores of SDSS in the 12(th) weekend of
treatment (5.93 ± 2.78) were significantly lower than those at baseline (13.9 ±
3.4) (t = 10.83, P < 0.05). In study group, the total scores of SDSS in the
12(th) weekend of treatment (5.9 ± 2.8) were significantly lower than those in
the 6(th) weekend of treatment (7.6 ± 2.9) (t = 5.21, P < 0.05). But there was no
significant improvement in control group (t = 1.88, P > 0.05). In the 12(th)
weekend of treatment, the total scores of SDSS in study group (5.9 ± 2.8) were
significantly lower than those in control group (8.8 ± 2.9) (t = -4.49, P <
0.05). No severe adverse effect was reported in either group.
CONCLUSION: Paliperidone extended-release tablets are effective to improve social
functions and psychiatric symptoms of schizophrenics.
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