A dose-response relationship research on botulinum toxin type A local intramuscular injections of lower extremity spasticity in children with cerebral palsy.

Author(s): Wang Y, Gao B

Affiliation(s): Department of Pediatrics, Beijing TianTan Hospital, Beijing 100050, China. yajienet@yahoo.com.cn

Publication date & source: 2008-05, Childs Nerv Syst., 24(5):545-7. Epub 2008 Feb 23.

Publication type: Randomized Controlled Trial

OBJECTIVES: To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy. METHODS: One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi (2) test. RESULTS: The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated. CONCLUSIONS: The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.