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Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery.

Author(s): Wang TF, Liu YH, Chu CC, Shieh JP, Tzeng JI, Wang JJ

Affiliation(s): Department of Anaesthesiology, Chi-Mei Medical Centre, Tainan, Taiwan. 400002@mail.chimei.org.tw

Publication date & source: 2008-02, Acta Anaesthesiol Scand., 52(2):280-4. Epub 2007 Nov 12.

Publication type: Randomized Controlled Trial

BACKGROUND: We evaluated the prophylactic effect of low-dose haloperidol (1 mg) on post-operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls. METHODS: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. After tracheal intubation, the haloperidol group (n=50) received intravenous haloperidol (1 mg), the droperidol group (n=50) received intravenous droperidol (0.625 mg), and the saline group (n=50) received intravenous saline. RESULTS: Haloperidol- and droperidol-group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P<0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P<0.05] during the first four post-operative hours. During the 24-h post-operative period, haloperidol- and droperidol-group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P<0.01]. No differences were found between the haloperidol and droperidol groups. CONCLUSION: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery.

Page last updated: 2008-03-26

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