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[The effect of tinidazole in the treatment of adult periodontitis]

Author(s): Wang R, Chen L, Ni K

Affiliation(s): Department of Stomatology, Zhejiang Provincial People's Hospital, Hangzhou.

Publication date & source: 1996-09, Zhonghua Kou Qiang Yi Xue Za Zhi., 31(5):303-6.

Publication type: Clinical Trial; Randomized Controlled Trial

Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group. The effective rate of TNZ in adult periodontitis patients was 73.1%, which was significantly higher than that of the control group (43.5%). Antimicrobial studies showed that the capability of TNZ to kill the periodontal dominant anaerobic bacteria, especially B. gingivalis and B. melaninogenicus, was better than that of MNZ. The minimal inhibitory concentration (MIC) of TNZ to Bacteroides, Fusobacterium, Veillonella, Eubacterium, Antinomyces, Peotostreptococus and Anaerobic Streptococus was lower than that of MNZ and actylspiramycine.

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