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[Celecoxib inhibits gastric adenocarcinoma growth via inducing expression of human nonsteroidal anti-inflammatory drug activated gene]

Author(s): Wang R, Ciren YJ, Yang JL, Zhang B, Chen JP, Tang CW

Affiliation(s): Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.

Publication date & source: 2009-11, Sichuan Da Xue Xue Bao Yi Xue Ban., 40(6):1029-32.

Publication type: English Abstract

OBJECTIVE: To investigate the effect of cyclooxygenase2 inhibitor celecoxib on the suppression of human gastric cancer (GC) growth and the induction of nonsteroidal anti-inflammatory drug activated gene (NAG-1) expression. METHODS: Thirty-six GC patients were randomly divided into two groups before curative surgery. Celecoxib group patients (n = 20) took celecoxib orally 0.2 g, qd for 7 days before operation. Control group (n = 16) took no medication before resection. The resected specimens were used for histological and pathological study, and apoptosis of tumor cells were evaluated by the terminal deoxynucleotide transferase (TdT)-mediated dUTP nick end-labeling assay (TUNEL). COX-2 expression was assessed by immunohistochemical staining. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) assay was used to measure NAG-1 mRNA expression in GC tissue of both groups. RESULTS: Apoptosis IOD score of the GC cells in celecoxib group was significantly higher than that in control group (180.2 +/- 42.67 vs 10.28 +/- 5.02, P < 0.05). NAG-1 mRNA expression was higher in celecoxib group (0.22 +/- 0.13) than in the control (0.12 +/- 0.08, P < 0.05). There was no significant difference of COX-2 expression rate between both groups (75.0% vs 87.6%, P > 0.05). CONCLUSION: Celecoxib can enhance apoptosis of GC cell by induction of NAG-1 gene transcription in human.

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