A randomized controlled trial of olanzapine improving memory deficits in Han
Chinese patients with first-episode schizophrenia.
Author(s): Wang CH(1), Li Y, Yang J, Su LY, Geng YG, Li H, Wang JK, Mu JL.
Affiliation(s): Author information:
(1)Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical
University, Xinxiang, Henan 453002, China.
Publication date & source: 2013, Schizophr Res. , 144(1-3):129-35
Olanzapine is an atypical antipsychotic for the treatment of schizophrenia, in
which memory impairment is a core deficit. The methods of positive and negative
syndrome scale (PANSS), Wechsler memory scale-4th edition (WMS-IV) and
event-related potential (ERP) were used to study the effects of olanzapine on the
cognitive function in the first-episode schizophrenic patients. We performed
multicentre, randomized, double-blind, placebo-controlled, parallel-group
clinical trial to study the cognitive functioning in Han Chinese first-episode
schizophrenic patients in a 12-week treatment regime with olanzapine (129 cases)
or placebo (132 cases). The results showed that (1) the patients with
first-episode schizophrenia showed significant deficits in the long-term memory,
short-term memory, immediate memory and memory quotient by WMS-IV assessment, and
decreases the total scores, positive symptoms, negative symptoms and general
psychopathology by PANSS assessment; (2) olanzapine could significantly improve
the PANSS scores including total scores, positive symptoms, negative symptoms and
general psychopathology in the first-episode schizophrenic patients; (3)
olanzapine could significantly improve the short-term memory, immediate memory
and memory quotient in the first-episode schizophrenic patients; and (3) although
the latencies of P(2), N(2) and P(3) were significantly prolonged, P(2) and P(3)
amplitudes were decreased and the latencies of N(1) did not change, olanzapine
did not influence any P(300) items in the first-episode schizophrenic patients.
The data suggested that that olanzapine could improve cognitive process, such as
memorizing and extraction of the information although there were many changes of
cognitive functions in Han Chinese first-episode schizophrenic patients.
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