Injection pain of prilocaine plain, mepivacaine plain, articaine with
epinephrine, and lidocaine with epinephrine.
Author(s): Wahl MJ, Schmitt MM, Overton DA.
Affiliation(s): Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Publication date & source: 2006, Gen Dent. , 54(3):168-71
In a double-blind study design, 1,391 consecutive patients in a general dental
practice received one of four different local anesthetics (articaine with
epinephrine, lidocaine with epinephrine, mepivacaine plain, or prilocaine plain)
via a maxillary buccal infiltration, palatal infiltration, or inferior alveolar
block injection. The anesthetics were administered under clinical conditions by
one of two dentists. Immediately after receiving the injection, patients rated
the pain from each injection on a ten-point scale. The pain response was analyzed
according to the dentist administering the injection, the location of injection,
the patient's gender, and the type of anesthetic administered. Injection of
prilocaine plain produced significantly lower pain scores than lidocaine with
epinephrine, mepivacaine plain, or articaine with epinephrine.
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