Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
Author(s): Wagenlehner FM, Kinzig-Schippers M, Tischmeyer U, Wagenlehner C, Sorgel F, Naber KG
Affiliation(s): Department of Urology, Hospital St. Elisabeth, St. Elisabeth Str. 23, D-94315 Straubing, Germany. Wagenlehner@AOL.com
Publication date & source: 2006-11, Antimicrob Agents Chemother., 50(11):3947-9. Epub 2006 Sep 18.
Publication type: Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Twelve volunteers received a single oral dose of 1,000 mg extended-release (XR) ciprofloxacin versus 500 mg levofloxacin to assess urinary bactericidal titers (UBTs) against common uropathogens. Areas under UBT-time curves were significantly larger for Proteus mirabilis with XR ciprofloxacin and for staphylococci with levofloxacin.
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