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Serum protein binding of desmethyl-methsuximide.

Author(s): Wad N, Bourgeois B, Kramer G

Affiliation(s): Swiss Epilepsy Centre, Zurich, Switzerland.

Publication date & source: 1999-07, Clin Neuropharmacol., 22(4):239-40.

Serum protein binding of desmethyl-methsuximide (DM-MSM) in serum from 23 patients on polytherapy were determined using ultrafiltration and high-performance liquid chromatography. Desmethyl-methsuximide, The active metabolite of methsuximide (MSM), was found to have a moderate protein binding ranging between 45% and 60%.

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