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Prevention of catheter-associated gram-negative bacilluria with norfloxacin by selective decontamination of the bowel and high urinary concentration.

Author(s): Vollaard EJ, Clasener HA, Zambon JV, Joosten HJ, van Griethuysen AJ

Affiliation(s): Department of Pharmacy, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

Publication date & source: 1989-06, J Antimicrob Chemother., 23(6):915-22.

Publication type: Clinical Trial; Controlled Clinical Trial; Randomized Controlled Trial

Oral norfloxacin prevented Gram-negative bacilluria in female patients with hip fractures, who needed medium-term transurethral catheterization. This was shown in a placebo-controlled double-blind study of 34 patients. Seventeen of these received a suspension containing 200 mg norfloxacin and 500 mg amphotericin B, twice daily. In the placebo group, six cases of Gram-negative bacilluria had occurred by day 7, as compared with no cases during a median time of catheterization of 23 days in the group on medication. Bacteriuria, either by Gram-positive cocci or by Gram-negative bacilli, was observed in 50% of patients on placebo by day 7; in the treatment group this was the case by day 17 (P less than 0.001). Subsequent bacteriuria with Gram-positive cocci was eliminated by nitrofurantoin (50 mg qid) within four days. Norfloxacin is very suitable for the prevention of Gram-negative bacilluria, because it decontaminates Gram-negative bacilli from the bowel, reaches high concentrations in urine and rarely produces resistant variants.

Page last updated: 2006-01-31

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